I'm glad you came here for support, atejadainc.
Yes, you can set up QuickBooks Desktop with Enhanced Payroll that you purchased from a retail store. I'm here to walk you through the whole process of activating your subscription.
Just in case you're having trouble activating your QuickBooks, here's an article you can refer to: Get help if you can’t activate QuickBooks Desktop.
Once done, you can start activating the payroll subscription through the steps provided below:
To learn more about activating QuickBooks Desktop Payroll subscriptions, feel free to check out this article: Activate a payroll service purchased from a retail store.
If you don't see Install Payroll from Box, your QuickBooks Desktop may already have a payroll subscription. I recommend you get in touch with our Payroll Support Team to activate your new payroll subscription.
You should be all set. Please let me know if you need more help setting up QuickBooks. I'm always around to assist you some more.