Hi there, @chrisjkennedy315.
I'm here to provide the best way in managing the vacation rental in QuickBooks Online.
First, you need to create a service item for the home rental. Here's how to do it:
Next, you can add the item when creating a sales transaction, either an invoice or a sales receipt.
That should help you manage the rental of your customers, @chrisjkennedy315.
I'm still here to help you more if you have additional questions. Just drop a comment below. Have a good day.