To resolve this, let's perform some steps so you'll be able to save your invoice. Let me walk you through the steps.
First, sign in to your QuickBooks Online account using a private window. This will allow the program to run without storing cache or cookies. Please follow these keyboard shortcuts to generate a private window:
Google Chrome: press Ctrl + Shift + N
Mozilla Firefox: press Ctrl + Shift + P
Microsoft Edge: press Ctrl + Shift + P
Safari: press Command + Shift + N
Once you're signed in, create an invoice again by going to the Sales menu.
Also, may I ask if you've encountered an error message? This way, I can make sure that we're on the same page so I can provide an accurate solution to your concern.
Additionally, if in case you want to change the layout or add a logo to your invoice, you can refer to this article for the detailed steps: Customize Invoices in QuickBooks Online.
Know that I am here anytime you need help with QuickBooks. Take care always.
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