I've checked our file and didn't see any cases similar to yours, Lexiegirl.
This unexpected behavior is probably caused by too much cache. Let's isolate this issue. To start with, let's open QuickBooks using an incognito window. This is the best place to isolate web issues. If you're able to create a new payrun from there, go back to your main browser, then clear the cache. This will help the program to load without any errors.
Moreover, using a different browser resolves issues like this (Google Chrome, Internet Explorer, or Mozilla Firefox).
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