Hello there, Teresa.
I am here to help you with your concerns about spreadsheet sync in QuickBooks Online (QBO).
It is possible to sync multiple line items to a single invoice using Spreadsheet Sync. Just use the Invoices template, enter each line item on a separate row in the spreadsheet, and ensure all rows for the same invoice share the same invoice number. Be sure all required fields are populated.

Please feel free to leave a comment below if you have further questions and concerns.