Having problems running pay roll since start of new tax year and getting update profile of employees before letting me run payrole manually, Have turned auto off. Not changed any settings so has something changed

Make sure all their information like personal details, tax info, and employment data is complete and accurate. A quick double-check can help keep things running smoothly. Here's how:
 

1. Go to Payroll tab.
2. Click Employees.
   
3. Review all the information and make sure there are no red exclamation warnings. If there is, you need to complete the missing information.
   
   
4. Hit Save.

Once you've updated everything, you can run payroll manually. 

For more detailed steps you can refer to this article: Add, update an employee record in QuickBooks Online.  

Additionally, I've also included this material to help generate different payroll reports to get an overview of how your business finances are going: Run payroll reports in QuickBooks Online Advanced Payroll.

If you have any other questions or need further assistance with running payroll, don't hesitate to get in touch.