Hi Dave,
You can record each eBay transaction as a sales receipt in QuickBooks Desktop. This way, your inventory will be adjusted at the same time you can match what was downloaded from Paypal.
I'm sharing these articles on how to create sales receipt and match the downloaded transactions:
Once done, run the Profit and Loss report in QuickBooks by going to Reports > Company & Financial > Profit and Loss.
Please let me know in the comments if you have any additional questions. Take care.