Hi jesseforen,
QuickBooks Desktop Pro Enhanced Payroll is a do-it-yourself option where you can process your payroll and file your taxes directly through QuickBooks. While in Assisted Payroll, someone will work on your payroll taxes and file returns for employees to keep them in compliance and a penalty-free guarantee.
You'll want to make sure that your QuickBooks Desktop is a supported version so you can run payroll. Please check this article for more information: How Do I Create A Paycheck For An Employee?.
For future reference, you'll want to change your subscription or upgrade to Assisted Payroll: Change Payroll Service.
If there's anything else you need. Please let me know so I can get back to you.