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Depending on your bank lead time, typically it can take two banking days for direct deposit to hit your employees bank accounts.
If you want to pay your employees Friday morning, make sure you submit your payroll by 5pm PST on Wednesday.
Further information regarding direct deposit and how it works can be found in this article.
If you'd like to request a direct deposit lead time change, you can reach out our QuickBooks Online care support here.
Should you need assistance with anything else, you can reach out here.
Best of luck!