I would like to run payroll for this week on Friday evening. I'm going on vacation next week, so I won't be able to run it on the usual Thursday of that week.

I'm glad to know that you'll be on a vacation next week, office264. 

I'm here to help and share some insights about payroll.

You can pay your employees in advance, and QuickBooks Online (QBO) will deduct the taxes based on the paycheck date.

If you use the direct deposit feature, you can read this article to learn more about when your employees are paid after submitting payroll: View or change your direct deposit funding time. It includes information on how to obtain funding more quickly.

For future reference, check out these articles for more information on payroll processing and how QBO handles payroll taxes:

• Create and run your payroll
• Payroll tax wage bases and limits

Do you require additional assistance in paying your employees in advance? Please let me know your response in the comments section below. I'd be happy to help you with it. Have a wonderful day ahead of you.