Nice to see you here in the Community space, @lilavalv.
Yes, you can apply those credits to reduce your IRS checks. You'll want to create a check to pay your payroll liabilities. Let me walk you through the steps.
In your QuickBooks Desktop (QBDT) software:
Go to the Employees menu and select Payroll Center.
Select the Pay Liabilities tab.
Mark the Federal 941 and other liabilities in the Pay Taxes & Other Liabilities section. Make sure the check amount and item list under Payroll Liabilities are accurate, and then select View/Pay.
On the Payroll Liabilities window, select Create.
Enter the National Paid Leave Credit, National Paid Leave - Health Premium and the amount of the 941 tax liabilities you qualify for based on the Payroll Item Detail Report you created. Enter the amount of the credit as a negative amount.
Select To be printed if you want to print the check.