Are there companies that use Quickbooks in Paraguay?

You can use QB Online Global version for Paraguay.

https://quickbooks.grsm.io/South-America

Another option, you can use QB Desktop US Premier edition for a Non Profit. You can still buy a one time license for QB Desktop 2021.

Any specific concern about your tax requirement?

They say there are differences as follows.
is it right?

Book of income and expenses.

National tax laws: A sheet should be reported to the ministry where the data and details of the income and expenses invoices are recorded. In Paraguay, all invoices have a random validation code provided by the ministry, a standardized correlative number, tax detail (5%, 10% or exempt from tax), type of invoice (cash or credit). All the accounting systems in the country, have the function of adding this data directly through a direct module, so as to report the forms directly from the system without having to load this information additionally outside the system.

QuickBooks: the system does not support a similar module to register all the information of each invoice. The developers of QuickBooks just recommended to add all the information in the memo of each transaction or to load simultaneously in a different platform.

Ask your team, what are the top 3 cloud based accounting apps they can use to meet tax requirements? You may consider a connector as a workaround later.