Good Morning, @nash_b.
Congrats on making your first post here in the Community. After looking further into this issue, I've discovered that there isn't an option available to make an item inactive in QuickBooks Point of Sale. However, I'm going to personally submit feedback to our Product Developers so they can consider this in one of the upcoming releases. They take the feedback given by customers very seriously.
If you want to learn more about QuickBooks Point of Sale, just check out this guide.
If you have any other questions, feel free to ask. I want to make sure that your concerns are addressed. Have a great day!