Greetings, @Mike Olear.
Let me begin by welcoming you to the Community. I just got the steps you need to change the default email account to send invoices from in QuickBooks Desktop.
To start sending invoices using your preferred email account, you need to configure your email service in the preferences window in QBDT.
Here’s how:
1. From the Edit menu, choose Preferences and select Send Forms.
2. Under My Preferences tab, click the Web Mail radio button and click Add.
3. Fill out the Add Email Info screen and click OK.
4. Ensure that the Use Enhanced Security checkbox is checked, then select OK.
5. Sign in to your Intuit account when prompted.
6. When your webmail provider’s login page displays, sign in and choose to grant Intuit access.
I've attached screenshots for your reference.



For more information, you may check out this article: Set up your email service in QuickBooks Desktop.
The steps above should help you set up a default email account to send invoices, reports and other transactions in QBDT.
Please let me know what else I can do to help you today. Thanks for coming to the Community, wishing you a wonderful rest of your day.