I appreciate you getting back and providing additional details about your issue.
To isolate the problem of why the report didn't save when doing some customization, we can run the Verify Rebuild Data tool that helps identify and repairs data issues within your company file. Here's what you'll need to do:
Go to Utilities, then choose Verify Data.
If QuickBooks detected no problems, there's no further action needed. If you receive a message, "Your data has lost integrity", the file is damaged. Just continue to Rebuild Data to correct the problem.
When you Rebuild Data, you'll receive a message to back up your company file, just click OK. The utility starts as soon as the back up is finished.
Click OK when you get the message "Rebuild has completed".
Run VerifyData again to check for remaining data damage.