File federal/state withholding for profit sharing disbursement

You should be able to make a journal entry with the appropriate Debits and credits. 

How do I generate the actual payment? It is not linked to payroll, so QB doesn't "know" anything about it and is not auto-generated with my regular tax payments. 

Thanks for the prompt reply, @Liz B.

You’ll want to create a Journal Entry (JE) as suggested by WonderShanae to generate the payment in your QuickBooks Desktop (QBDT). Let me show you how:

1. Go to the Company menu.
2. Select Make General Journal Entries.
3. Fill out the fields to create your journal entry. Make sure your debits equal your credits.
4. Click Save or Save & Close when done.

You can also check this article for more details: Create a journal entry in QuickBooks Desktop for Windows or Mac.

If you’re unsure of what accounts to debit and credit, I recommend working with your accountant for guidance. This way, we can ensure the accuracy of your accounts after recording this.

If you’re not affiliated with one, you can visit our ProdAvisor page and find one from there. Let me also add this article that you can use for your future reference: Reconcile an account in QuickBooks Desktop. This link can walk you through the steps in matching your transactions effectively.

You can always get back to me if you have any other concerns or follow-up questions about recording your tax payment in QuickBooks. I’ll be around to back you up. Have a good one!