My only reservation about Backups, though I make them daily, is that I've seen them fail. And I just had a long conversation with a friend yesterday on his company having a potentially major issue with lost data because someone opted to Backup vs Archive in the wrong situation.
If you're going to be making substantial changes within a day or two I think you're safer making multiple uncompressed copies and then just deleting the whole folder of the copies when you're done.
And weren't you the one discussing a while back about the various weaknesses of the QB database. :)
But bottom line, have multiple copies in one form or another after you make each major group of changes. So if there is a need to back step, you're not going back to square one and wasting all of the time you've already put into the project.