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Hello Mary53, you can run QuickBooks as Administrator. Running the application with administrative privileges can often bypass permission restrictions that prevent updates or file access.
Open the Windows Start menu. Type in "QuickBooks" into the search tab. Right-click on the QuickBooks version and year you wish to open from the results. Select Run as administrator. Run the payroll update. After completing the update, close QuickBooks and reopen it normally, without using administrator privileges.
If running QuickBooks as an administrator does not resolve the issue, you need to manually adjust the security permissions for the QuickBooks program file. For more information, please refer to Step 2 highlighted in this article: Fix "File you specified cannot be opened" or "File exists" errors.
Although the article above is written for the US region, the steps can also be applicable in your region.
The Community team is always available if you need anything else.