Had the same thing happen and I found that Profile put 1.00 on line 50340 even though there was no CPP withheld and no CPP Pensionable earnings on T4.  Wasted 20 minutes at peak tax time comparing this year's return to last year's to try and determine where the error was.  Exact same return as last year except there was no amount in 50340 in 2022. 

Over rode 50340 and deleted the 1.00.  Efile went through.

I don't understand why this program (that is not new) has so many faults.  If you want to hire me for quality assurance you are welcome to contact me but I suppose it's cheaper to have your paying clients figure it out for you.