System glitches, browser-related problems, or device-specific issues are some factors why you're unable to save your invoices in QuickBooks Online (QBO), John.
Before we start, could you please provide me with any specific error messages or additional details about what happens when you try to save your invoices? Also, may I know what device you're using? This will help us provide a tailored solution to your concern.
In the meantime, let's perform some basic troubleshooting steps by signing into your QBO account using any supported browser or clearing your browser's cache to refresh the performance.
Next, you'll want to restart your browser and log back into your account to verify if your invoices are already saving as expected.
Feel free to reply to this post if you need further assistance.