Hi KeepAcc, thanks for your post - you can submit CIS suffered to HMRC on the EPS after running payroll, we've got a guide linked with the steps to follow for QB standard payroll - if you're using QB advanced payroll, you can enter this by selecting Payroll > Reports > Employer Payment Summary > CIS > enter the cumulative amount for the relevant month. Please get back to us below if you're have any further issues when following these steps. :)