Hi @christine-bulbec
You should be able to post any number of payments against a Bill > via Bill Payments or (from the Invoice itself > Make Payment).
Similarly, Receive Payments to post against Invoices.
The CIS-ness of the Bill/Invoice shouldn't matter.
However, exactly how QBO will treat for CIS purposes, I'm not sure - I have CIS activated in QBO but do not use it for CIS submissions. QBO doesn't (unless it's been fixed) deal correctly with CIS Supplier Credits.
Your best bet is to try applying multiple payments - check whether it affects the CIS Return as you'd expect, if not post a follow up & see if a workaround can be found.
Hope this helps.