Hello there Nick,
In QuickBooks Online (QBO), the Inclusive of Tax on an invoice means that the price you enter for a product or service already includes the sales tax. The total amount on the invoice reflects the exact sum you want the customer to pay, without any additional tax being added at the end.
For example, if you sell a $100 item with a 10% tax rate, the $100 price tag already includes the tax. This means the item's actual price is about $90.91, and the remaining $9.09 is the tax.
If the price wasn't inclusive of tax, you would see the item for $100, and then an additional $10 in tax would be added, for a total of $110.
Feel free to comment below if you have additional questions about taxes in QuickBooks Online.