Hello Peter,
Thanks for your post, great to see the detail required! In my experience as technical support; i think you will be able to set this all up, - I'd get an Pro-Advisor qualified Accountant, a specialist in QB; to assist you in being compliant.
You have 5 separate sales income streams each with their own expenses and direct commission creditors and direct payments.
This income of yours will all eventually landing in your current account from which is drawn our checking account and direct debits etc
You can set up multiple income streams on QB, these can be categorized and have expenses, commission and payments come out of each of those streams; you'd then deposit the remaining into your current account. You'd do this through the use of an "Undeposited Funds" account, or possibly through the use of income/asset accounts. Formally, this is where the accountant comes in as i can't tell you which type of account you "Should" use for your business.
Have you created a trial account and just run some tests? You don't have to subscribe when selecting trial.