Payroll is very complicated and if you don't know what you are doing, will cost you $$ in penalties for late payments and late filings.  It is correct that you are required to file quarterly, monthly and annual forms related to payroll.  Additionally, you will need to apply form unemployment and state withholding accounts. 

QuickBooks offers varied payroll subscriptions or you can contact a payroll service such as ADP or Paychex to help you out.  As I stated, the penalties for improper payroll transaction is costly.