It's great to have you join this forum, Deadwood Al. Let me provide information to help you handle commissions for employees when running payroll.
Yes, you can pay employees commission on a regular payroll processing. Applying for these commission payments on regular pay will calculate the same taxes when filing. You may exclude the commission amount on the paycheck created when running a regular payroll of every two weeks.
![sample commission.png sample commission.png](https://quickbooks.intuit.com/learn-support/image/serverpage/image-id/97654i560E8761CD8B9C1F/image-size/large?v=v2&px=999)
In addition to that, you may consider reaching out to your tax advisor to seek additional guidance in managing this process.
Moreover, you may want to utilize this reference when filing and paying federal taxes electronically: E-file and e-pay federal forms and taxes in QuickBooks Desktop Payroll Enhanced.
I'll keep this thread available for any additional queries when paying employee commissions in your account. Just let me know below, so I can get you covered. Stay safe and have a great one!