Hi there, @annie-amalfitano.
Let me help figure out why you're not able to pay your taxes directly through QuickBooks.
You'll need to sign up to Eservices first if you're going to pay your unemployment tax via Epay. We recommend signing up for e-file and e-pay in QuickBooks Online even if you're already set up to file and pay electronically with the IRS or state agencies. You can check this article for more details: https://community.intuit.com/articles/1430981-sign-up-for-e-file-and-e-pay.
However, if you need to pay taxes manually or with a check, you can refer to this article: Pay taxes with e-pay or check.
I'm confident these resources will help you with paying your payroll taxes directly through QuickBooks. I'm here to help if you need anything else.