Yes, it will, @JDEAL.
Setting up an inventory item in your Inventory List will automatically add two accounts to your company file's Chart of Accounts. Using multiple accounts in the item list isn't a factor when calculating average cost and asset value. However, each inventory item requires an income account.
Here's an article you can read to learn more about managing your inventory in your QuickBooks Desktop (QBDT) software: Understand inventory assets and cost of goods sold tracking.
Furthermore, do check our Help articles page for future reference. There, you can read some of our great articles that can guide you in your future tasks.
Let me know if there's anything else you need help with by leaving a comment. I'll be around to help you anytime. Take care!