Hello there, @lighthouseupc238.
Setting up the tax-exempt for non-profit in QuickBooks Self- Employed is unavailable. Self-employment tax is a Social Security and Medicare tax primarily for individuals who work for themselves.
You can read more information in these links about self-employed tax obligations:
Also, you can check this article to know the right version of QuickBooks fits on your needs: Choose the right version of QuickBooks.
Please feel free to let me know if you have any other concerns. Take care.