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Hello there, proedgerenovatio,
For now, inserting e-signature to an estimate isn't available in QuickBooks Online.
You have the option to download the estimate in PDF. Then, use an app editor and insert the signature from there. After that, you can print and send it to your customer.
To do so, the following steps will guide you through:
I've added the Set up and use estimates page to learn more about this transactions in QuickBooks.
You can also check out these video tutorials to help manage your customers.
Stay in touch if there's anything else you need. I'm always around to help.
Thank you and stay safe!
Explore this 3rd party app for your needs.