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The creation of a purchase order shouldn't affect your ledger since it's a non-posting transaction.
Let's check if it's a data issue by running the Verify Data Utility tool. This helps resolve unexpected behavior like this.
Here's how:
Or you can do the following to rebuild your data:
For more detailed instructions, I'd recommend checking this article: Resolve data damage on your company file.
Keep me posted for additional info after performing the steps or any other concerns. I'd be more than happy to help.