Thank you for reaching out to the QuickBooks Community, Gator88. Yes, there is a way to exclude certain classes when running your Profit and Loss report in QuickBooks Desktop. I will be delighted to show you how to do so.

1.  Go to the Report tab, then Company & Financial and select Profit and Loss Details or Standard.
2. Make the necessary adjustments, such as setting the date ranges and Report Basis.
3. Select the Customize Report option.
4. In the Modify Report screen, under Filter, use the search bar and type class.
5. In the drop-down bar, instead of all classes, choose multiple classes.
6. Pick all that applies and click OK when finished.
7. Select OK again to save the changes.

You should have your customized report now showing the specific classes you wanted. For more information on how to make adjustments to reports, I recommended this article that is filled with ways to achieve this.

If you need any more assistance, the Community and I will be here at all times to help you. Have an awesome weekend and take care!