Can I assign an invoice no. manually (don't want to start at 1001) but then have the system assign consecutive numbers for the next invoices starting at my assigned no.?

See this article on customize invoice numbers:

https://quickbooks.intuit.com/community/Income-and-expenses/How-to-change-the-invoice-number-on-sale...

This process does not work.  As you see here, I enabled custom invoice numbers, created a sequence (2100-2102), then disabled customised numbers.  The next invoice number was 1005.  Why?

Hi there, @mikeincairns. 

Thanks for visiting the Community. I'd be glad to provide some insights about using custom transaction numbers in QuickBooks Online.

When you use this feature and decides to turn it off after setting up your desired invoice number, QuickBooks will begin assigning consecutive numbers to each new invoice you create. 

Since it didn't apply to your next invoice, we can delete the current invoice (1005). Then, let's turn the Custom transaction numbers feature again and set the next number sequence. 

Here's how: 

1. Go to the Gear icon, then select Account and Settings.
2. Click Sales, then click anywhere within the Sales form content section.
3. Check the box next to Custom transaction numbers.
4. Select Save, then Done.
5. Open an invoice form, then enter the next sequence number (2103) in the Invoice no. field. Please note that the sequence applies to all sales forms.

Turn off the feature, then create a new invoice and see if it follows the sequence.

If the issue persists, I'd recommend you contact our Customer Care team so we can further review what's causing this to happen and help you resolve the issue. We can also submit a case to investigate this further whenever necessary. 

For future reference, read through this article: How to show transaction numbers on sales forms. This feature lets your customer know how many transactions they've done with you. 

I'm always around here to help if you have other concerns about customizing invoice number. Have a great day. 

After posting that's exactly what I tried.  I manually created another invoice number (#2103).  Then I returned to automatic numbering to created another invoice.  It created 1006.  So it is not working.

Sorry I posted the results to another post Re: How do I change the starting invoice number in... (intuit.com).