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QuickBooks Error 15243 usually appears when we're trying to update QuickBooks Desktop. There are many factors that can trigger this error, I've listed them below:
I encourage visiting this link to be guided in repairing your QuickBooks Desktop for Windows.
You can also perform the troubleshooting steps that I've listed below to resolve this error. Before diving in, let's make sure that we're using the latest version of QuickBooks and we've already secured a backup of your company file.
First, we'll have to close your QuickBooks, then enable the QuickBooks Desktop File Copy Service:
Once done, re-validate the payroll's service key to refresh the connection:
I would also recommend updating getting the latest payroll tax table update to help isolate the issue.
If there's anything else that I can help you with, please don't hesitate to drop a comment to this thread. I'll be right here to keep helping.