Hi there, @ischram.

I appreciate you letting us know the result of the troubleshooting steps you've performed on your end. I want to ensure this issue is resolved, so you can get back to business.

Currently, there's an open investigation where customers are getting the error you encounter. Our engineers are currently researching why these errors are occurring. They are requesting log files and system details from users that are experiencing these errors. That said, I recommend you contact our QuickBooks Customer Care Team if you haven't yet. They can add you to our list of affected users, and you'll receive an email notification once an update is available.

Once requested log files and systems details are sent, here's some resolutions steps that you can try:

Solution 1. Run as Administrator:

1. Open the Windows Start menu.
2. Type “QuickBooks” into the search.
3. You should see your results listed in the Search window.
4. Right-click on the QuickBooks version and year you wish to open.
5. Select Run as administrator.
6. Run the payroll update.
7. Once complete, close QuickBooks and open it normally (not running as admin).

However, if the error persists, proceed to Solution 2 on this article: How to fix payroll errors: “The file you specified cannot be opened” and “The file exists”.

Please let me know how things go on your end. I'll be here to keep helping. Have a great day.