payroll will not launch after update 22601

Good morning, lsw5.

Thanks for joining us here in the Community. I want to make sure you're able to run payroll in your QuickBooks Desktop account.

Getting kicked out of QuickBooks Desktop (QBDT) Payroll after an update often means there is a corrupted update, security issue, or multi-user conflict. The good news is this is typically a quick fix. Here are few solution options to try:

1. Run as Administrator: Right-click the QBDT icon and select "Run as administrator".
2. Restart & Single-User Mode: Close QBDT, restart your computer, then open QuickBooks and immediately go to File > Switch to Single-User Mode before accessing payroll.
3. Re-verify Service Key: Go to Employees > My Payroll Service > Manage Service Key, click Edit, re-enter your service key, and click Finish (uncheck "Open Payroll Setup"). 

The following articles offer additional info about troubleshooting QBDT Payroll errors:

• Troubleshoot Payroll Service Server Error or Payroll Connection Error
• Fix payroll errors: The file you specified cannot be opened and The file exists

Please don't hesitate to reach back out if you have any other questions. I'll be here to lend a hand.